Getting expelled from school isn't so bad, but when Sabu's goons start getting in the way of buying the newest video game, it becomes personal. After defeating the Yakuza leader Sabuko (and kicking her out a window for good measure), delinquent schoolgirls Misako and Kyoko earned the ire of her father, Sabu, who breaks out of prison to ruin the lives of the duo. River City Girls 2 begins not long after the original game.